DNA methylation profiling in human lung tissue identifies genes associated with COPD.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a smoking-related disease characterized by genetic and phenotypic heterogeneity. Although association studies have identified multiple genomic regions with replicated associations to COPD, genetic variation only partially explains the susceptibility to lung disease, and suggests the relevance of epigenetic investigations. We performed genome-wide DNA methylation profiling in homogenized lung tissue samples from 46 control subjects with normal lung function and 114 subjects with COPD, all former smokers. The differentially methylated loci were integrated with previous genome-wide association study results. The top 535 differentially methylated sites, filtered for a minimum mean methylation difference of 5% between cases and controls, were enri

SUBMITTER: Morrow JD 

PROVIDER: S-EPMC5094634 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature