Experimental Evolution Reveals Interplay between Sch9 and Polyploid Stability in Yeast.

ABSTRACT: Polyploidization has crucial impacts on the evolution of different eukaryotic lineages including fungi, plants and animals. Recent genome data suggest that, for many polyploidization events, all duplicated chromosomes are maintained and genome reorganizations occur much later during evolution. However, newly-formed polyploid genomes are intrinsically unstable and often quickly degenerate into aneuploidy or diploidy. The transition between these two states remains enigmatic. In this study, laboratory evolution experiments were conducted to investigate this phenomenon. We show that robust tetraploidy is achieved in evolved yeast cells by increasing the abundance of Sch9-a protein kinase activated by the TORC1 (Target of Rapamycin Complex 1) and other signaling pathways. Overexpressing SCH9,

SUBMITTER: Lu YJ 

PROVIDER: S-EPMC5094715 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature