Circulating Folate and Vitamin B₁₂ and Risk of Prostate Cancer: A Collaborative Analysis of Individual Participant Data from Six Cohorts Including 6875 Cases and 8104 Controls.

ABSTRACT:

Background

Folate and vitamin B₁₂ are essential for maintaining DNA integrity and may influence prostate cancer (PCa) risk, but the association with clinically relevant, advanced stage, and high-grade disease is unclear.

Objective

To investigate the associations between circulating folate and vitamin B₁₂ concentrations and risk of PCa overall and by disease stage and grade.

Design, setting, and participants

A study was performed with a nested case-control design based on individual participant data from six cohort studies including 6875 cases and 8104 controls; blood collection from 1981 to 2008, and an average follow-up of 8.9 yr (standard deviation 7.3). Odds ratios (ORs) of incident PCa by study-specific fifths of circulating folate and vitami

SUBMITTER: Price AJ 

PROVIDER: S-EPMC5094800 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature