Functional oncogene signatures guide rationally designed combination therapies to synergistically induce breast cancer cell death.

ABSTRACT: A critical first step in the personalized approach to cancer treatment is the identification of activated oncogenes that drive each tumor. The Identification of driver oncogenes on a patient-by-patient basis is complicated by the complexity of the cancer genome and the fact that a particular genetic alteration may serve as a driver event only in a subset of tumors that harbor it. In this study, we set out to identify the complete set of functional oncogenes in a small panel of breast cancer cell lines. The cell lines in this panel were chosen because they each contain a known receptor tyrosine kinase (RTK) oncogene. To identify additional drivers, we integrated functional genetic screens with copy number and mutation analysis, and cancer genome knowledge databases. The resulting functional

SUBMITTER: Guest ST 

PROVIDER: S-EPMC5094989 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature