A unique set of 6 circulating microRNAs for early detection of non-small cell lung cancer.

ABSTRACT:

Introduction

Circulating microRNAs are promising biomarkers for diagnosis, predication and prognostication of diseases. Lung cancer is the cancer disease accountable for most cancer deaths, largely due to being diagnosed at late stages. Therefore, diagnosing lung cancer patients at an early stage is crucial for improving the outcome. The purpose of this study was to identify circulating microRNAs for detection of early stage lung cancer, capable of discriminating lung cancer patients from those with chronic obstructive pulmonary disease (COPD) and healthy volunteers.

Results

We identified 7 microRNAs separating lung cancer patients from controls. By using RT-qPCR, we validated 6 microRNAs (miR-429, miR-205, miR-200b, miR-203, miR-125b and miR-34b) with a significantly higher

SUBMITTER: Halvorsen AR 

PROVIDER: S-EPMC5095073 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature