A critical role of solute carrier 22a14 in sperm motility and male fertility in mice.

ABSTRACT: We previously identified solute carrier 22a14 (Slc22a14) as a spermatogenesis-associated transmembrane protein in mice. Although Slc22a14 is a member of the organic anion/cation transporter family, its expression profile and physiological role have not been elucidated. Here, we show that Slc22a14 is crucial for sperm motility and male fertility in mice. Slc22a14 is expressed specifically in male germ cells, and mice lacking the Slc22a14 gene show severe male infertility. Although the overall differentiation of sperm was normal, Slc22a14^-/- cauda epididymal spermatozoa showed reduced motility with abnormal flagellar bending. Further, the ability to migrate into the female reproductive tract and fertilise the oocyte were also impaired in Slc22a14^-/- spermatozoa. The abn

SUBMITTER: Maruyama SY 

PROVIDER: S-EPMC5095606 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature