An Aldol Reaction-Based Iridium(III) Chemosensor for the Visualization of Proline in Living Cells.

ABSTRACT: A long-lived aldol reaction-based iridium(III) chemosensor [Ir(ppy)₂(5-CHOphen)]PF₆ (1, where ppy = 2-phenylpyridine and 5-CHOphen = 1,10-phenanthroline-5-carbaldehyde) for proline detection has been synthesized. The iridium(III) complex 1, incorporating an aldehyde group in N^N donor ligand, can take part in aldol reaction with acetone mediated by proline. The transformation of the sp²-hybridized carbonyl group into a sp³-hybridized alcohol group influences the metal-to-ligand charge-transfer (MLCT) state of the iridium(III) complex, resulting in a change in luminescence in response to proline. The interaction of the iridium(III) complex 1 with proline was investigated by ¹H NMR, HRMS and emission titration experiments. Upon the addit

SUBMITTER: Liu JB 

PROVIDER: S-EPMC5095674 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature