Aluminium chloride promotes tumorigenesis and metastasis in normal murine mammary gland epithelial cells.

ABSTRACT: Aluminium salts, present in many industrial products of frequent use like antiperspirants, anti-acid drugs, food additives and vaccines, have been incriminated in contributing to the rise in breast cancer incidence in Western societies. However, current experimental evidence supporting this hypothesis is limited. For example, no experimental evidence that aluminium promotes tumorigenesis in cultured mammary epithelial cells exists. We report here that long-term exposure to concentrations of aluminium-in the form of aluminium chloride (AlCl₃ )-in the range of those measured in the human breast, transform normal murine mammary gland (NMuMG) epithelial cells in vitro as revealed by the soft agar assay. Subcutaneous injections into three different mouse strains with decreasing immun

SUBMITTER: Mandriota SJ 

PROVIDER: S-EPMC5095782 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature