Replication of genome-wide association study (GWAS) susceptibility loci in a Latino bipolar disorder cohort.

ABSTRACT:

Objectives

Recent genome-wide association studies (GWASs) have identified numerous putative genetic polymorphisms associated with bipolar disorder (BD) and/or schizophrenia (SC). We hypothesized that a portion of these polymorphisms would also be associated with BD in the Latino American population. To identify such regions, we tested previously identified genetic variants associated with BD and/or SC and ancestral haploblocks containing these single nucleotide polymorphisms (SNPs) in a sample of Latino subjects with BD.

Methods

A total of 2254 Latino individuals were genotyped for 91 SNPs identified in previous BD and/or SC GWASs, along with selected SNPs in strong linkage disequilibrium with these markers. Family-based single marker and haplotype association testing was pe

SUBMITTER: Gonzalez S 

PROVIDER: S-EPMC5095871 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature