Genomic Variants Associated with Resistance to High Fat Diet Induced Obesity in a Primate Model.

ABSTRACT: Maternal obesity contributes to an increased risk of lifelong morbidity and mortality for both the mother and her offspring. In order to better understand the molecular mechanisms underlying these risks, we previously established and extensively characterized a primate model in Macaca fuscata (Japanese macaque). In prior studies we have demonstrated that a high fat, caloric dense maternal diet structures the offspring's epigenome, metabolome, and intestinal microbiome. During the course of this work we have consistently observed that a 36% fat diet leads to obesity in the majority, but not all, of exposed dams. In the current study, we sought to identify the genomic loci rendering resistance to obesity despite chronic consumption of a high fat diet in macaque dams. Through extensive phenot

SUBMITTER: Harris RA 

PROVIDER: S-EPMC5095882 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature