Ontology highlight
ABSTRACT:
SUBMITTER: Xie N
PROVIDER: S-EPMC5095888 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Xie Nan N Ma Liwei L Zhu Feng F Zhao Wenhui W Tian Feng F Yuan Fuwen F Fu Jingxuan J Huang Daoyuan D Lv Cuicui C Tong Tanjun T
Scientific reports 20161104
Nucleolar proteins play an important role in the regulation of the MDM2-p53 pathway, which coordinates cellular response to stress. However, the mechanism underlying this regulation remains poorly understood. Here, we report that the nucleolar protein CSIG is a novel and crucial regulator of the MDM2-p53 pathway. We demonstrate that CSIG translocates from the nucleolus to the nucleoplasm in response to nucleolar stress. Moreover, knockdown of CSIG attenuates the induction of p53 and abrogates G1 ...[more]