Responses to drugs of abuse and non-drug rewards in leptin deficient ob/ob mice.

ABSTRACT:

Rationale

Although leptin receptors are found in hypothalamic nuclei classically associated with homeostatic feeding mechanisms, they are also present in brain regions known to regulate hedonic-based feeding, natural reward processing, and responses to drugs of abuse. The ob/ob mouse is deficient in leptin signaling, and previous work has found altered mesolimbic dopamine signaling and sensitivity to the locomotor activating effects of amphetamine in these mice.

Objectives

We directly assessed responses to three drugs of abuse and non-drug rewards in the leptin-deficient ob/ob mouse.

Methods

Ob/ob mice were tested in assays of sweet preference, novelty seeking, and drug reward/reinforcement.

Results

In assays of novelty seeking, novel open field activity and op

SUBMITTER: Muelbl MJ 

PROVIDER: S-EPMC5095929 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature