Discrepancies between cortical and behavioural long-term readouts of hyperalgesia in awake freely moving rats.

ABSTRACT:

Background

It is still unclear to what extent the most common animal models of pain and analgesia, based on indirect measures such as nocifensive behaviours, provide valid measures of pain perception.

Methods

To address this issue, we developed a novel animal model comprising a more direct readout via chronically (>1 month) implanted multichannel electrodes (MCE) in rat primary somatosensory cortex (S1; known to be involved in pain perception in humans) and compared this readout to commonly used behavioural pain-related measures during development of hyperalgesia. A translational method to induce hyperalgesia, UVB irradiation of the skin, was used. Localized CO₂ laser stimulation was made of twenty skin sites (20 stimulations/site/observation day) on the plantar h

SUBMITTER: Ljungquist B 

PROVIDER: S-EPMC5096034 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature