HIV-free survival at 12-24 months in breastfed infants of HIV-infected women on antiretroviral treatment.

ABSTRACT:

Objective

To provide estimates of HIV-free survival at 12-24 months in breastfed children by maternal ART (6 months or lifelong) to inform WHO HIV and Infant Feeding guidelines.

Methods

Eighteen studies published 2005-2015 were included in a systematic literature review (1295 papers identified, 156 abstracts screened, 55 full texts); papers were analysed by narrative synthesis and meta-analysis of HIV-free survival by maternal ART regimen in a random effects model. We also grouped studies by feeding modality. Study quality was assessed using a modified Newcastle-Ottawa Scale (NOS) and GRADE.

Results

The pooled estimates for 12-month HIV-free survival were 89.8% (95% confidence interval, CI: 86.5%, 93.2%) for infants of mothers on ART for 6 months post-natally (six stu

SUBMITTER: Chikhungu LC 

PROVIDER: S-EPMC5096069 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature