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1,5-Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid-β(1-40) Fibrillization.

ABSTRACT: Biologically relevant 1,5-diazacyclooctanes derived from polyamines and acrolein, inhibit Aβ40 peptide fibrillization and significantly suppress cell cytotoxicity. Formal [4+4] cycloaddition reaction of imines is thus involved in modulating oxidative stress processes associated with neural diseases.

SUBMITTER: Tsutsui A

PROVIDER: S-EPMC5096251 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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1,5-Diazacyclooctanes, as Exclusive Oxidative Polyamine Metabolites, Inhibit Amyloid-<i>β</i>(1-40) Fibrillization.

Tsutsui Ayumi A Zako Tamotsu T Bu Tong T Yamaguchi Yoshiki Y Maeda Mizuo M Tanaka Katsunori K

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20160601 10

<b>Biologically relevant 1,5-diazacyclooctanes</b> derived from polyamines and acrolein, inhibit Aβ40 peptide fibrillization and significantly suppress cell cytotoxicity. Formal [4+4] cycloaddition reaction of imines is thus involved in modulating oxidative stress processes associated with neural diseases. ...[more]

PMID: 27840798

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