Serological markers to measure recent changes in malaria at population level in Cambodia.

ABSTRACT:

Background

Serological markers for exposure to different Plasmodium species have recently been used in multiplex immunoassays based on the Luminex technology. However, interpretation of the assay results requires consideration of the half-life of specific antibodies against these markers. Therefore, the aim of the present study was to document the half-life of malaria specific serological makers, as well as assessing the sensitivity of these markers to pick up recent changes in malaria exposure.

Methods

A recently developed multiplex immunoassay was used to measure the intensity of antibody (Ab) responses against 19 different Plasmodium specific antigens, covering different human malaria parasites and two vector saliva antigens. Therefore, 8439 blood samples from five cross-

SUBMITTER: Kerkhof K 

PROVIDER: S-EPMC5096337 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature