Amygdala-Cortical Connectivity: Associations with Anxiety, Development, and Threat.

ABSTRACT:

Background

Amygdala-prefrontal cortex (PFC) functional connectivity may be influenced by anxiety and development. A prior study on anxiety found age-specific dysfunction in the ventromedial PFC (vmPFC), but not amygdala, associated with threat-safety discrimination during extinction recall (Britton et al.). However, translational research suggests that amygdala-PFC circuitry mediates responses following learned extinction. Anxiety-related perturbations may emerge in functional connectivity within this circuit during extinction recall tasks. The current report uses data from the prior study to examine how anxiety and development relate to task-dependent amygdala-PFC connectivity.

Methods

Eighty-two subjects (14 anxious youths, 15 anxious adults, 25 healthy youths, 28 healthy

SUBMITTER: Gold AL 

PROVIDER: S-EPMC5096647 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature