Analysis of the association between the LUM rs3759223 variant and high myopia in a Japanese population.

ABSTRACT:

Purpose

Many studies have investigated the relationship of the lumican gene (LUM) rs3759223 variant with the risk of high myopia, but the results have been inconsistent and inconclusive. In this study, we investigated whether LUM rs3759223 is associated with high myopia in a Japanese population.

Methods

We recruited 1,585 Japanese patients with high myopia (spherical equivalent [SE] <-9.00 diopters [D]) and 1,011 Japanese healthy controls (SE ≥-1.00 D). The rs3759223 variant was genotyped using the TaqMan assay, and the allelic and genotypic diversity among cases and controls was analyzed according to the SE level.

Results

In the allelic tests, the odds ratio (OR) for the T allele of rs3759223 tended to increase with the progression of SE, and the highes

SUBMITTER: Okui S 

PROVIDER: S-EPMC5096747 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature