Altered homotopic connectivity in postherpetic neuralgia: a resting state fMRI study.

ABSTRACT:

Objective

The aim of this study was to explore interhemispheric intrinsic connectivity in patients with postherpetic neuralgia (PHN).

Methods

We obtained resting-state functional magnetic resonance imaging data from 18 right-handed PHN patients (11 males, 7 females; mean age, 59.67±8.41 years) and 18 well-matched healthy controls (11 males, 7 females; mean age, 38.50±7.51 years). Interhemispheric connectivity was examined using voxel-mirrored homotopic connectivity (VMHC), and seed-based functional connectivity analysis was performed.

Results

Compared with the healthy controls, the patients with PHN showed abnormally decreased homotopic connectivity in the dorsolateral prefrontal cortex and the precuneus and posterior cingulate cortex (PCUN/PCC). The decreased VMHC in

SUBMITTER: Jiang J 

PROVIDER: S-EPMC5096754 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature