Tiered Human Integrated Sequence Search Databases for Shotgun Proteomics.

ABSTRACT: The results of analysis of shotgun proteomics mass spectrometry data can be greatly affected by the selection of the reference protein sequence database against which the spectra are matched. For many species there are multiple sources from which somewhat different sequence sets can be obtained. This can lead to confusion about which database is best in which circumstances-a problem especially acute in human sample analysis. All sequence databases are genome-based, with sequences for the predicted gene and their protein translation products compiled. Our goal is to create a set of primary sequence databases that comprise the union of sequences from many of the different available sources and make the result easily available to the community. We have compiled a set of four sequence database

SUBMITTER: Deutsch EW 

PROVIDER: S-EPMC5096980 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature