Towards real-time topical detection and characterization of FDG dose infiltration prior to PET imaging.

ABSTRACT:

Purpose

To dynamically detect and characterize ¹⁸F-fluorodeoxyglucose (FDG) dose infiltrations and evaluate their effects on positron emission tomography (PET) standardized uptake values (SUV) at the injection site and in control tissue.

Methods

Investigational gamma scintillation sensors were topically applied to patients with locally advanced breast cancer scheduled to undergo limited whole-body FDG-PET as part of an ongoing clinical study. Relative to the affected breast, sensors were placed on the contralateral injection arm and ipsilateral control arm during the resting uptake phase prior to each patient's PET scan. Time-activity curves (TACs) from the sensors were integrated at varying intervals (0-10, 0-20, 0-30, 0-40, and 30-40 min) post-FDG and the result

SUBMITTER: Williams JM 

PROVIDER: S-EPMC5096989 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature