Individual-specific principal component analysis of circulating inflammatory mediators predicts early organ dysfunction in trauma patients.

ABSTRACT:

Purpose

We hypothesized that early inflammation can drive, or impact, later multiple organ dysfunction syndrome (MODS), that patient-specific principal component analysis (PCA) of circulating inflammatory mediators could reveal conserved dynamic responses which would not be apparent from the unprocessed data, and that this computational approach could segregate trauma patients with regard to subsequent MODS.

Methods

From a cohort of 472 blunt trauma survivors, 2 separate subcohorts of moderately/severely injured patients were studied. Multiple inflammatory mediators were assessed in serial blood samples in the first 24 hours postinjury. PCA of these time course data was used to derive patient-specific "inflammation barcodes," followed by hierarchical clustering to define pat

SUBMITTER: Namas RA 

PROVIDER: S-EPMC5097026 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature