Neuroprotective effect of a novel Chinese herbal decoction on cultured neurons and cerebral ischemic rats.

ABSTRACT:

Background

Historically, traditional Chinese medicine has been widely used to treat stroke. Based on the theory of Chinese medicine and the modern pharmacological knowledge of herbal medicines, we have designed a neuroprotective formula called Post-Stroke Rehabilitation (PSR), comprising seven herbs - Astragalus membranaceus (Fisch.) Bunge, Salvia miltiorrhiza Bunge, Paeonia lactiflora Pall., Cassia obtusifolia L., Ligusticum chuanxiong Hort., Angelica sinensis (Oliv.) Diels, and Glycyrrhiza uralensis Fisch. We aim to examine the neuroprotective activity of PSR in vitro and in vivo, and to explore the underlying molecular mechanisms, to better understand its therapeutic effect and to further optimize its efficacy.

Methods

PSR extract or vehicle was applied to primary rat neu

SUBMITTER: Ip FC 

PROVIDER: S-EPMC5097373 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature