Differential DNA methylation marks and gene comethylation of COPD in African-Americans with COPD exacerbations.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is the third-leading cause of death worldwide. Identifying COPD-associated DNA methylation marks in African-Americans may contribute to our understanding of racial disparities in COPD susceptibility. We determined differentially methylated genes and co-methylation network modules associated with COPD in African-Americans recruited during exacerbations of COPD and smoking controls from the Pennsylvania Study of Chronic Obstructive Pulmonary Exacerbations (PA-SCOPE) cohort.

Methods

We assessed DNA methylation from whole blood samples in 362 African-American smokers in the PA-SCOPE cohort using the Illumina Infinium HumanMethylation27 BeadChip Array. Final analysis included 19302 CpG probes annotated to the nearest gene tr

SUBMITTER: Busch R 

PROVIDER: S-EPMC5097392 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature