Serum from obstructive sleep apnea patients induces inflammatory responses in coronary artery endothelial cells.

ABSTRACT:

Background and aims

Obstructive sleep apnea (OSA) is characterized by intermittent airway obstruction and systemic hypoxia during sleep, which can contribute to an increase in reactive oxygen species, vascular remodeling, vasoconstriction and ultimately cardiovascular disease. Continuous positive airway pressure (CPAP) is a clinical therapy that maintains airway patency and mitigates several symptoms of OSA. However, it is currently unknown whether CPAP therapy also reduces the overall inflammatory potential in the circulation; to address this in an unbiased manner, we applied a novel endothelial biosensor approach, the serum cumulative inflammatory potential (SCIP) assay.

Methods

We studied healthy controls (n = 7), OSA subjects receiving no treatment, (OSA controls) (n = 7

SUBMITTER: Zychowski KE 

PROVIDER: S-EPMC5097675 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature