Tumour CD274 (PD-L1) expression and T cells in colorectal cancer.

ABSTRACT:

Objective

Evidence suggests that CD274 (programmed death-ligand 1, B7-H1) immune checkpoint ligand repress antitumour immunity through its interaction with the PDCD1 (programmed cell death 1, PD-1) receptor of T lymphocytes in various tumours. We hypothesised that tumour CD274 expression levels might be inversely associated with T-cell densities in colorectal carcinoma tissue.

Design

We evaluated tumour CD274 expression by immunohistochemistry in 823 rectal and colon cancer cases within the Nurses' Health Study and Health Professionals Follow-up Study. We conducted multivariable ordinal logistic regression analyses to examine the association of tumour CD274 expression with CD3⁺, CD8⁺, CD45RO (PTPRC)⁺ or FOXP3⁺ cell density in tumou

SUBMITTER: Masugi Y 

PROVIDER: S-EPMC5097696 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature