Septic shock with no diagnosis at 24 hours: a pragmatic multicenter prospective cohort study.

ABSTRACT:

Background

The lack of a patent source of infection after 24 hours of management of shock considered septic is a common and disturbing scenario. We aimed to determine the prevalence and the causes of shock with no diagnosis 24 hours after its onset, and to compare the outcomes of patients with early-confirmed septic shock to those of others.

Methods

We conducted a pragmatic, prospective, multicenter observational cohort study in ten intensive care units (ICU) in France. We included all consecutive patients admitted to the ICU with suspected septic shock defined by clinical suspicion of infection leading to antibiotic prescription plus acute circulatory failure requiring vasopressor support.

Results

A total of 508 patients were admitted with suspected septic shock. Amo

SUBMITTER: Contou D 

PROVIDER: S-EPMC5097846 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature