Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study).

ABSTRACT: Previous studies have shown several metabolic biomarkers to be associated with prevalent and incident atrial fibrillation (AF), but the results have not been replicated. We investigated metabolite profiles of 2,458 European ancestry participants from the Framingham Heart Study without AF at the index examination and followed them for 10 years for new-onset AF. Amino acids, organic acids, lipids, and other plasma metabolites were profiled by liquid chromatography-tandem mass spectrometry using fasting plasma samples. We conducted Cox proportional hazard analyses for association between metabolites and new-onset AF. We performed hypothesis-generating analysis to identify novel metabolites and hypothesis-testing analysis to confirm the previously reported associations between metabolites and

SUBMITTER: Ko D 

PROVIDER: S-EPMC5097881 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature