Effect of CMV and Aging on the Differential Expression of CD300a, CD161, T-bet, and Eomes on NK Cell Subsets.

ABSTRACT: Natural killer (NK) cells are innate lymphoid cells involved in the defense against virus-infected cells and tumor cells. NK cell phenotype and function is affected with age and cytomegalovirus (CMV) latent infection. Aging affects the frequency and phenotype of NK cells, and CMV infection also contributes to these alterations. Thus, a reduction of CD56^bright NK cell subpopulation associated with age and an expansion of memory-like NK cells CD56^dimCD57⁺NKG2C⁺ probably related to CMV seropositivity have been described. NK cells express T-bet and Eomes transcription factors that are necessary for the development of NK cells. Here, we analyze the effect of age and CMV seropositivity on the expression of CD300a and CD161 inhibitory receptors, and T-b

SUBMITTER: Lopez-Sejas N 

PROVIDER: S-EPMC5097920 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature