Ontology highlight
ABSTRACT:
SUBMITTER: Wong JP
PROVIDER: S-EPMC5098123 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Cell reports 20161001 5
Subunits of the SWI/SNF chromatin remodeling complex are mutated in a significant proportion of human cancers. Malignant rhabdoid tumors (MRTs) are lethal pediatric cancers characterized by a deficiency in the SWI/SNF subunit SMARCB1. Here, we employ an integrated molecular profiling and chemical biology approach to demonstrate that the receptor tyrosine kinases (RTKs) PDGFRα and FGFR1 are coactivated in MRT cells and that dual blockade of these receptors has synergistic efficacy. Inhibitor comb ...[more]