Human Non-Hematopoietic CD271^pos/CD140a^low/neg Bone Marrow Stroma Cells Fulfill Stringent Stem Cell Criteria in Serial Transplantations.

ABSTRACT: Human bone marrow contains a population of non-hematopoietic stromal stem/progenitor cells (BMSCs), which play a central role for bone marrow stroma and the hematopoietic microenvironment. However, the precise characteristics and potential stem cell properties of defined BMSC populations have not yet been thoroughly investigated. Using standard adherent colony-forming unit fibroblast (CFU-F) assays, we have previously shown that BMSCs were highly enriched in the nonhematopoietic CD271^pos/CD140a^low/neg fraction of normal adult human bone marrow. In this study, we demonstrate that prospectively isolated CD271^pos/CD140a^low/neg BMSCs expressed high levels of hematopoiesis supporting genes and signature mesenchymal and multipotency genes on a single c

SUBMITTER: Ghazanfari R 

PROVIDER: S-EPMC5098131 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature