Characterization of T follicular helper cells in allogeneic normal pregnancy and PDL1 blockage-induced abortion.

ABSTRACT: A deeper understanding of the immunological events during pregnancy will provide novel insights into the pathogenesis of pregnancy complications. The fundamental function of T follicular helper (Tfh) cells is to provide cognate help to B cells. Dysregulations of Tfh-cell function and/or development can result in various immunological diseases. However, the role and characteristics of Tfh cells during pregnancy remain unknown. Herein, an allogeneic-normal-pregnant mouse model was used, and we found that the CD4⁺ T cells residing at the uterus and placenta (UP) displayed a Tfh-like phenotype; and the UP-derived CD4⁺CXCR5^hiPD-1^hi and CD4⁺CXCR5^hiICOS^hi Tfh cells, which showed a memory/activation phenotype, reached the

SUBMITTER: Zeng W 

PROVIDER: S-EPMC5098204 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature