Effects of cerebellar theta-burst stimulation on arm and neck movement kinematics in patients with focal dystonia.

ABSTRACT:

Objective

To investigate the cerebellar inhibitory influence on the primary motor cortex in patients with focal dystonia using a cerebellar continuous theta-burst stimulation protocol (cTBS) and to evaluate any relationship with movement abnormalities.

Methods

Thirteen patients with focal hand dystonia, 13 patients with cervical dystonia and 13 healthy subjects underwent two sessions: (i) cTBS over the cerebellar hemisphere (real cTBS) and (ii) cTBS over the neck muscles (sham cTBS). The effects of cerebellar cTBS were quantified as excitability changes in the contralateral primary motor cortex, as well as possible changes in arm and neck movements in patients.

Results

Real cerebellar cTBS reduced the excitability in the contralateral primary motor cortex in healthy s

SUBMITTER: Bologna M 

PROVIDER: S-EPMC5098212 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature