Metabolic Abnormalities Related to Treatment With Selective Serotonin Reuptake Inhibitors in Patients With Schizophrenia or Bipolar Disorder.

ABSTRACT:

Objective

The aim of the present study was to examine the effect of selective serotonin reuptake inhibitors (SSRIs) on cardiovascular risk factors in patients with schizophrenia or bipolar disorder.

Method

We used data from a cross-sectional study on 1301 patients with schizophrenia or bipolar disorder, of whom 280 were treated with SSRIs. The primary outcome variable was the serum concentration of total cholesterol. Secondary outcome variables were low-density lipoprotein (LDL) cholesterol, high-density lipoprotein cholesterol, triglyceride and glucose levels, body mass index, waist circumference, and systolic and diastolic blood pressure.

Results

After adjusting for potential confounders, an SSRI serum concentration in the middle of the reference interval was associ

SUBMITTER: Fjukstad KK 

PROVIDER: S-EPMC5098465 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature