Antiplatelet and Antithrombotic Effects of the Extract of Lindera obtusiloba Leaves.

ABSTRACT: Lindera obtusiloba has been used in traditional herbal medicine for the treatment of blood stasis and inflammation. The leaves of Lindera obtusiloba have been reported to exhibit various physiological activities. However, there is little information available on their antiplatelet and antithrombotic activities. Thus, the present study aimed to evaluate the effect of Lindera obtusiloba leaf extract (LLE) on platelet activities, coagulation and thromboembolism. In a platelet aggregation study, LLE significantly inhibited various agonist-induced platelet aggregations in vitro and ex vivo. Furthermore, LLE significantly inhibited collagen-induced thromboxane A2 (TXA2) production in rat platelets. In addition, oral administration of LLE was protective in a mou

SUBMITTER: Kim JH 

PROVIDER: S-EPMC5098546 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature