Noninvasive Transdermal Vaccination Using Hyaluronan Nanocarriers and Laser Adjuvant.

ABSTRACT: Vaccines are commonly administered by injection using needles. Although transdermal microneedles are less-invasive promising alternatives, needle-free topical vaccination without involving physical damage to the natural skin barrier is still sought after as it can further reduce needle-induced anxiety and simply administration. However, this long-standing goal has been elusive since the intact skin is impermeable to most macromolecules. Here, we show an efficient, non-invasive transdermal vaccination in mice by employing two key innovations: first, the use of hyaluronan (HA) as vaccine carriers and, second, non-ablative laser adjuvants. Conjugates of a model vaccine ovalbumin (OVA) and HA-HA-OVA conjugates-induced more effective maturation of dendritic cells in vitro, compared to OV

SUBMITTER: Kim KS 

PROVIDER: S-EPMC5098559 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature