Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors.

ABSTRACT: In humans, errors in meiotic chromosome segregation that produce aneuploid gametes increase dramatically as women age, a phenomenon termed the "maternal age effect." During meiosis, cohesion between sister chromatids keeps recombinant homologs physically attached and premature loss of cohesion can lead to missegregation of homologs during meiosis I. A growing body of evidence suggests that meiotic cohesion deteriorates as oocytes age and contributes to the maternal age effect. One hallmark of aging cells is an increase in oxidative damage caused by reactive oxygen species (ROS). Therefore, increased oxidative damage in older oocytes may be one of the factors that leads to premature loss of cohesion and segregation errors. To test this hypothesis, we used an RNAi strategy to induce oxidativ

SUBMITTER: Perkins AT 

PROVIDER: S-EPMC5098651 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature