Effect of Ionic Diffusion on Extracellular Potentials in Neural Tissue.

ABSTRACT: Recorded potentials in the extracellular space (ECS) of the brain is a standard measure of population activity in neural tissue. Computational models that simulate the relationship between the ECS potential and its underlying neurophysiological processes are commonly used in the interpretation of such measurements. Standard methods, such as volume-conductor theory and current-source density theory, assume that diffusion has a negligible effect on the ECS potential, at least in the range of frequencies picked up by most recording systems. This assumption remains to be verified. We here present a hybrid simulation framework that accounts for diffusive effects on the ECS potential. The framework uses (1) the NEURON simulator to compute the activity and ionic output currents from multicompartm

SUBMITTER: Halnes G 

PROVIDER: S-EPMC5098741 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature