Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention.

ABSTRACT:

Background

The relationship between lower sodium intake and total mortality remains controversial.

Objectives

This study examined the relationship between well-characterized measures of sodium intake estimated from urinary sodium excretion and long-term mortality.

Methods

Two trials, phase I (1987 to 1990), over 18 months, and phase II (1990 to 1995), over 36 months, were undertaken in TOHP (Trials of Hypertension Prevention), which implemented sodium reduction interventions. The studies included multiple 24-h urine samples collected from pre-hypertensive adults 30 to 54 years of age during the trials. Post-trial deaths were ascertained over a median 24 years, using the National Death Index. The associations between mortality and the randomized interventions as well a

SUBMITTER: Cook NR 

PROVIDER: S-EPMC5098805 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature