Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve.

ABSTRACT:

Background

In patients with myocardial infarction (MI), leaflet tethering by displaced papillary muscles induces mitral regurgitation (MR), which doubles mortality. Mitral valves (MVs) are larger in such patients but fibrosis sets in counterproductively. The investigators previously reported that experimental tethering alone increases mitral valve area in association with endothelial-to-mesenchymal transition.

Objectives

The aim of this study was to explore the clinically relevant situation of tethering and MI, testing the hypothesis that ischemic milieu modifies mitral valve adaptation.

Methods

Twenty-three adult sheep were examined. Under cardiopulmonary bypass, the papillary muscle tips in 6 sheep were retracted apically to replicate tethering, short of producing M

SUBMITTER: Dal-Bianco JP 

PROVIDER: S-EPMC5099077 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature