Project description:Our study aimed to better understand the immune responses during an acute asthma exacerbation in children. Gene expression profiles were examined by RNA-sequencing in blood samples. Samples were collected on average 2.5 day after systemic corticosteroid treatment. Our findings show that pro-inflammatory genes and pathways related to innate responses and signaling remained increased in children hospitalized for acute asthma exacerbation. Genes and pathways involved in adaptive immune respones, particularly T lymphocyte activation, were decreased in children hospitalized for acute asthma exacerbation. These studies suggest that innate immune responses may remain activated following hospitalization for asthma exacerbation.

2024-06-17 | GSE256534 | GEO

Association Between Obesity and Acute Severity Among Patients Hospitalized for Asthma Exacerbation.

Project description: Not available

| S-EPMC7723818 | biostudies-literature

Innate Immune Responses by Respiratory Viruses, Including Rhinovirus, During Asthma Exacerbation.

Project description: Not available

| S-EPMC9250977 | biostudies-literature

Ability of Serum IgE Concentration to Predict Exacerbation Risk and Benralizumab Efficacy for Patients with Severe Eosinophilic Asthma.

Project description: Not available

| S-EPMC7004419 | biostudies-literature

Innate immune responses are increased in children with acute asthma exacerbation.

Project description: Not available