Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes T_H17 cell differentiation.

ABSTRACT:

Background

The autosomal recessive hyper-IgE syndrome (HIES) caused by dedicator of cytokinesis 8 (DOCK8) deficiency shares clinical features with autosomal dominant HIES because of signal transducer and activator of transcription 3 (STAT3) mutations, including recurrent infections and mucocutaneous candidiasis, which are suggestive of T_H17 cell dysfunction. The mechanisms underlying this phenotypic overlap are unclear.

Objective

We sought to elucidate common mechanisms operating in the different forms of HIES.

Methods

We analyzed the differentiation of CD4⁺ T_H cell subsets in control and DOCK8-deficient subjects. We also examined the role of DOCK8 in regulating STAT3 activation in T cells. T_H cell differentiation was analyz

SUBMITTER: Keles S 

PROVIDER: S-EPMC5099100 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature