Dietary composition affects the development of cognitive deficits in WT and Tg AD model mice.

ABSTRACT: Clinical and epidemiological evidence suggests that lifestyle factors, including nutrition, may influence the chances of developing of Alzheimer's disease (AD), and also likely affect the aging process. Whereas it is clear that high-fat diets are increasing both body weight and the risk of developing Alzheimer's disease, to date, there have been very few studies comparing diets high with different sources of calories (i.e., high fat versus high protein versus high carbohydrates) to determine whether dietary composition has importance beyond the known effect of high caloric intake to increase body weight, AD pathology and cognitive deficits. In the current study we examined the effects that different diets high in carbohydrate, protein or fat content, but similar in caloric value, have on t

SUBMITTER: Kadish I 

PROVIDER: S-EPMC5099116 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature