Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology.

ABSTRACT:

Objective

Proteinase-activated receptor 2 (PAR2) deficiency protects against cartilage degradation in experimental osteoarthritis (OA). The wider impact of this pathway upon OA-associated pathologies such as osteophyte formation and pain is unknown. Herein, we investigated early temporal bone and cartilage changes in experimental OA in order to further elucidate the role of PAR2 in OA pathogenesis.

Methods

OA was induced in wild-type (WT) and PAR2-deficient (PAR2^-/-) mice by destabilisation of the medial meniscus (DMM). Inflammation, cartilage degradation and bone changes were monitored using histology and microCT. In gene rescue experiments, PAR2^-/- mice were intra-articularly injected with human PAR2 (hPAR2)-expressing adenovirus. Dynamic weight beari

SUBMITTER: Huesa C 

PROVIDER: S-EPMC5099200 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature