Reproducibility of ¹⁸F-fluoromisonidazole intratumour distribution in non-small cell lung cancer.

ABSTRACT:

Background

Hypoxic tumours exhibit increased resistance to radiation, chemical, and immune therapies. ¹⁸F-fluoromisonidazole (FMISO) positron emission tomography (PET) is a non-invasive, quantitative imaging technique used to evaluate the presence and spatial distribution of tumour hypoxia. To facilitate the use of FMISO PET for identification of individuals likely to benefit from hypoxia-targeted treatments, we investigated the reproducibility of FMISO PET spatiotemporal intratumour distribution in patients with non-small cell lung cancer (NSCLC).

Methods

Ten patients underwent ¹⁸F-fluorodeoxyglucose (FDG) PET/CT scans, followed by two FMISO PET/CT scans 1-2 days apart. Nineteen lesions in total were segmented from co-registered FDG PET image sets. Vol

SUBMITTER: Grkovski M 

PROVIDER: S-EPMC5099292 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature