Developmental profiling of ASD-related shank3 transcripts and their differential regulation by valproic acid in zebrafish.

ABSTRACT: SHANK3 is a scaffolding protein that binds to various synaptic proteins at the postsynaptic density (PSD) of excitatory glutamatergic synapses. SHANK3 is not only strongly implicated in autism spectrum disorders (ASD) but also plays a critical role in human Phelan-McDermid syndrome (22q13.3 deletion syndrome). Accumulated experimental evidence demonstrates that the zebrafish model system is useful for studying the functions of ASD-related gene during early development. However, many basic features of shank3 transcript expression in zebrafish remain poorly understood. Here, we investigated temporal, spatial, and isoform-specific expression patterns of shank3 during zebrafish development on the basis of previous researches and the differential effects of each shank3 transcript expression aft

SUBMITTER: Liu CX 

PROVIDER: S-EPMC5099374 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature