STAT4 gene polymorphism in patients after renal allograft transplantation.

ABSTRACT:

Introduction

STAT4 (signal transducer and activator of transcription 4) is involved in the regulation of innate and adaptive immune responses. Some studies have suggested that STAT4 may be involved in the immune response after graft transplantation. Several polymorphisms in the STAT4 gene have been identified. The most commonly studied polymorphism in the STAT4 gene is rs7574865. In our study, we examined whether this polymorphism is associated with the early and late functions of renal allografts.

Material and methods

A total of 270 recipients of first renal transplants were included in the study. Single nucleotide polymorphisms (SNPs) within the STAT4 gene were genotyped using TaqMan genotyping assays.

Results

There were no statistically significant associations bet

SUBMITTER: Dabrowska-Zamojcin E 

PROVIDER: S-EPMC5099381 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature