Pharmacokinetics and effects of demographic factors on blood 25(OH)D3 levels after a single orally administered high dose of vitamin D3.

ABSTRACT:

Aim

To examine the biological consequences and demographic factors that might affect the pharmacokinetics of vitamin D3 after a single high dose intervention in a young Chinese population with vitamin D insufficiency status.

Methods

A total of 28 young subjects (25 to 35 years old) with vitamin D insufficiency status [serum 25(OH)D <30 ng/mL] was recruited in Shanghai, China. The subjects were orally administered a single high dose of vitamin D3 (300 000 IU). Baseline characteristics and blood samples were collected at d 0, 1, 2, 3, 7, 28, 56, 84 and 112 after the intervention. The blood biomarker levels were determined with standardized methods.

Results

The intervention markedly increased the blood 25(OH)D3 levels within the first five days (mean T_max=5.1±

SUBMITTER: Chen PZ 

PROVIDER: S-EPMC5099415 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature