Pharmacokinetics of oral fludrocortisone in septic shock.

ABSTRACT:

Aim

The combination of hydrocortisone and fludrocortisone improved outcomes in septic shock. However, the specific role of fludrocortisone remains controversial and its pharmacokinetics (PK) has never been investigated in septic shock. This study aimed at characterizing the PK of fludrocortisone in septic shock.

Methods

This was a single-centre ancillary PK study of a large multinational trial of crystalloids versus colloids for acute hypovolemia in intensive care unit (ICU) patients. In 21 adults with septic shock, fludrocortisone plasma concentrations were measured by liquid chromatography-mass spectrometry tandem analysis, before and repeatedly until 18 h after an oral dose of 50 μg. PK parameters were estimated using a nonlinear mixed-effects modelling.

Results

Un

SUBMITTER: Polito A 

PROVIDER: S-EPMC5099539 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature