Prevalence and characteristics of adverse drug reactions at admission to hospital: a prospective observational study.

ABSTRACT:

Aims

Adverse drug reactions (ADRs) contribute to poorer patient outcomes and additional burden to the healthcare system. However, data on the true burden, relevant types and drugs causing ADRs are lacking. The aim of this study was to determine the prevalence of ADR-related hospitalization in the general adult population in Singapore and to investigate their characteristics.

Methods

We prospectively recruited 1000 adult patients with unplanned admission to a large tertiary-care hospital. Two independent reviewers evaluated all suspected ADRs for causality, type, severity and avoidability. The prevalence of ADR-related hospitalization was calculated based on 'definite' and 'probable' ADRs. Logistic regression was used to evaluate predictors for having an ADR at admission.

SUBMITTER: Chan SL 

PROVIDER: S-EPMC5099543 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature